Changes in the EV-A71 Genome through Recombination and Spontaneous Mutations: Impact on Virulence
Ship Model Kit Enterovirus 71 (EV-A71) is a major etiological agent of hand, foot and mouth disease (HFMD) that mainly affects young children less than five years old.The onset of severe HFMD is due to neurological complications bringing about acute flaccid paralysis and pulmonary oedema.In this review, we address how genetic events such as recombi